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Ewe eje is safe and healthy for consumption. One of the numerous nutritional benefits of justicia carnea leaves is in the possession of various forms of the B vitamins such as Vitamin B1, B2, B6, B9, and B12. All authors read and approved the final draft of the manuscript. Tropical habitats mean constant moisture. There may be some problems if the air is too dry in winter. In recent time, copious attention has been focused on the use of medicinal plants in the management and treatment of ailments such as anemia, diabetes and malaria. Grows up to 4-6 ft. tall (120-180 cm) and 2-3 ft. wide (60-90 cm). Gas chromatography/mass spectrometry of simple coumarins, 3-phenylpropionic acids and their hydroxy and methoxy derivatives. However, lowest (50mg/kg) dose of extract significantly elevated MCH and MCHC. Mounanga MB, Mewonob L, Angone SA. Inhibitory Potential and Antidiabetic Activity of Leaf Extracts of Justicia carnea. Clin Phytosci 7, 2 (2021). Feed the soil when the cutting is new to encourage better growth. Having discussed the nutritional benefits of ewe eje, i shall now take you through the various health benefits of justicia carnea leaves, and roots. The haematological indices of the blood samples were determined using an automated URIT 2900 Plus 3 Differential Haematological Analyzer. They protect our cells from the harmful effects of reactive oxygen species. Also observed is a distortion in the walls of the blood vessels (red arrow), pyknotic hepatocytes and signs of inflammation (red arrow), Photomicrographs of kidney sections stained with Haematoxylin and Eosin (Mag. White blood cell counts usually increases following foreign invaders (pathogens) resulting in normal body physiological response which boost the bodys defense mechanisms [28, 29]. The weight of organs (liver and kidney) reduced steadily in a concentration dependent manner. Effects of kolaviron on hepatic oxidative stress in streptozotocin induced diabetes. The plant is hardy to USDA Hardiness Zones 8b through 11. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Powdered sample (1000g) was soaked in absolute ethanol (3000mL) with constant stirring. Anaemia is a common blood disorder that affects people of all ages, though people at greater risk are the elderly, young women and infants. Walters DM., Cho Hye-Youn, Kleeberger SR. Oxidative Stress and Antioxidants in the Pathogenesis of Pulmonary Fibrosis: A Potential Role for Nrf2. Justicia carnea is commonly cultivated and grown as an ornamental potted plant. Hence, Justicia carnea can be used to strengthen the immune system. Justicia Betonica Herb Uses, Benefits, Cures, Side Effects, Nutrients Different drugs are used but many depend mainly on plants and herbal products for its treatment. -Amylase binding-interaction with JCAE was also investigated using fluorescence spectroscopy and molecular docking. This is due to the inability of the pancreatic beta cells to secrete insulin, which transports glucose to cells, or the inability of cells of the body to recognize insulin. 2017;16(2):21730 https://doi.org/10.17306/J.AFS.2017.0492. PDF Evaluation of Anti-inflammatory and Analgesic Properties of Justicia Materials and Methods Justicia carnea (Brazilian Plume) is an upright, evergreen shrub with large, dark green leaves, 10 in. Cite this article. Anthonia OC, Ikechukwu UR, Uzoma NO, Sunday ELU. 2. Rich, well-drained soil retaining ample moisture is the perfect home for Brazilian plume flowers. In traditional medicine, justicia carnea is used in treating hepatitis. List of various diseases cured by Justicia Betonica. J. Pharmacogn. View abstract. Onyeabo C, Achi NK, Ekeleme-Egedigwe CA, Ebere CU, Okoro CK. This is in agreement with previous work on the reversed effect of J. carnea leaf extract on anaemia induced experimental rat [9, 21]. Whether added to garden beds or pots, the justicia (plant) adds a colorful tropical touch and are easy to grow. The possible anti-anaemic property of the leaf could be linked to the improved hemoglobin, PCV and RBC observed in this study. Google Scholar. 2016;5(1):6270 https://doi.org/10.1016/j.joad.2015.08.006. However, caution should be taken as higher dose at 1200mg/kg could cause noticeable tissue injury. Not sure which Justicia to pick?Compare All Justicia. Justicia carnea is affects Fertility according to a researched article published on ResearchgateJusticia carnea was found to lower sperm count Male Wistar Albino ratsthe effect of this herb on female fertility is not yet known. Pompella A, Visvikis A, Paolicchi A, De Tata V, Casini AF. 1. 2. Rats that received 50 and 100mg/kg body weight JCEE showed significant (p<0.05) increase in liver weight while other doses showed no significant difference compared to the control. Water your plants deeply during growth periods, allowing the soil to dry . View abstract. Ewe eje can increase blood count and volume. The gradual decrease in the weight of organs following short-term exposure of J. carnea leaf ethanol extract may be attributed to adaptive response of the organs arising from daily dosage of the extract or its metabolites within their body. In these groups, from mild to severe order; the renal cortex appears distorted, Renal glomeruli and dillated capsular spaces appeared collapsed with characteristic pyknosis of the mesangial cells, The renal tubules, interstitial spaces, appears distorted with presence of red inflammatory cells, hemorrhagic cells infiltrating the renal interstitial spaces as well as focal sclerosis of renal glomeruli with associated degeration of the glomerular membrane (red arrows). long (20 cm), densely packed with pink to crimson tubular flowers. Ewe eje is mainly given to persons who want a blood boost such as pregnant women, persons suffering from anemia and other convalescents. Yes my readers. Use liquid fertilizers, slow-release or granulated formulas. This special leaf can be found around us- in our neighborhood. Caterpillars may be an occasional problem, chewing down on some of the foliage. The renal tubules and interstitial spaces appears distorted with presence of red inflammatory cells infiltrating the renal interstitial spaces as well as focal sclerosis of renal glomeruli with associated degeration of the glomerular membrane. In the study conducted by Onyeabor and his colleagues, it was shown that the leaf extract not only reverses anemic condition, but also lowered the lipid profile of the experimental rats. Pinch out tips to promote compact plants. The levels of white blood cell count, lymphocyte, granulocyte and MID could indicate that ethanol extract of J. carnea leaf pose no toxicity or sub acute inflammation to the overall defense mechanism and immunity of the experimental rats. The botanical name- Justicia carnea was coined after a scotish- James Justice, who happens to have found the plant first. It is not. PDF Journal La Lifesci Lorke D. A new approach to practical acute toxicity testing. The catalase activity was calculated using the expression: Note: A=change in absorbance, TV=total volume, TP=total protein, SV=sample volume, =molar extinction=40M1 cm1. National Research Council. Becoming a contributing member of Gardenia is easy and can be done in just a few minutes. Ethanol extract of J. carnea leaf elevated red blood cell, hemoglobin, packed cell volume and platelet count with significant increase at higher doses of extracts compared to the control. https://doi.org/10.3390/molecules191221442. Backfill the soil gently, filling the empty space around the root ball and then press it down with your hands. The Pros and Cons of Creatine You Should Know. 2008;108(9):14807. In an acute exposure of experimental rats to single oral doses of extract, no mortality and signs of adverse effects were observed. Justicia carnea is a medicinal plant that is used conventionally as blood tonic from time immemorial in Nigeria. Cover and leave for about fifteen minutes. How to make Ewe eje Extracthow to prepare justicia carnea. Accept de Vries, J. X., Tauscher, B., and Wurzel, G. Constituents of Justicia pectoralis Jacq. Cut back after flowering to 2-3 nodes from the ground to keep the plant bushy and promote new blooms. In subacute study, rats were randomized into six groups of five rats per group: Group 1 (control) received distilled water, group 2, 3, 4, 5, 6 received 50, 100, 500, 800 and 1200mg/kg body weight of J. carnea ethanol extract once daily using oral gavage. J Ethnopharmacol. Studies on the Phytochemical and Nutritional Composition of Aqueous Leaf Extract of Justicia Carnea and its Effect on Some Biochemical Parameters in Anaemic Rats. A total number of forty two (42) male albino rats weighing between 120 and 170g were used in this study. Microsomal lipid peroxidation. 400). if you add justicia carnea leaves in avocado seed tea, you may just get yourself the best remedy for cardiovascular diseases. In which ever condition, the blood glucose level increases abnormally. They range in colors such as red, orange, mauve, magenta, apricot, and pink. Hepatic and renal damage has been recently linked with the use of medicinal plants in the treatment of various diseases [5, 6]. Nutritive properties of aqueous extract Justicia carnea leaves and its effects on haematological and some biochemical indices of anaemia induced male wistar albino rats. Nutritive properties of aqueous extract Justicia carnea leaves and its Plantcaretoday.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to amazon.com, how to get rid of leaf eating caterpillar. Although, medically, it is advised you see your doctor or a physician before using the leaf for medicinal uses. The aqueous leaf extract of ewe eje has demonstrated hypoglycaemic and antidiabetic properties; and thus, can be said to assist with blood sugar levels reduction. We currently have no information for JUSTICIA PECTORALIS overview. Filed in Biochemistry Project Topics, Current Projects by TMLT Editorials on September 22, 2020. Joseph, H., Gleye, J., Moulis, C., Mensah, L. J., Roussakis, C., and Gratas, C. Justicidin B, a cytotoxic principle from Justicia pectoralis. https://doi.org/10.4314/njps.v19i1.32627. The minerals present in justicia carnea (Ewe eje or ogwu obara) are calcium, iron, magnesium, copper and zinc. When it comes to fertilizing, an NPK balance of 5-10-5 will work well, encouraging blooming and strong growth. de Smet, P. A. Significant (P<0.05) decrease observed in liver total protein of rat administered with 1200mg/kg of extract could be due to intrinsic factors in-vivo that might not necessarily indicate adverse reaction of the extracts. Compared to the control, total protein in liver and kidney were statistically not altered except rats that were administered with 1200mg/kg JCEE that showed significant (p<0.05) decrease in the liver. We'll respect your privacy and unsubscribe at any time. It creates the perfect environment for aphids and dried sod. Justicia Carnea leaves extract contains a rich supply of iron, riboflavin, vitamins A, C, E, B1, B2, B9, and B12. II. https://doi.org/10.1186/s40816-020-00234-4, DOI: https://doi.org/10.1186/s40816-020-00234-4. Daily intake of the Ewe eje or ajeri can increase the absorption of iron and vitamins, Uses and health benefits of Ewe eje (Justicia carnea leaf). As reported by science, Justicia carnea is composed of secondary metabolites such as: flavonoids, terpenoids, alkaloids, phenols, saponins and tannins. Privacy According to acute toxicity grading standards, LD50 of substances greater than 5000mg/kg is practically considered non-toxic [22, 23]. Ewe eje as a Natural Blood booster/tonic: Due to the high concentration of iron in this leaf, it can help boost blood production by increasing the red blood cells, haemoglobin, and the blood platelets. The resultant liquid would turn crimson red. long (25 cm), and showy flower plumes, 8 in. Mukinda JT, Syce JA. Nigeria's medicinal plant: Justicia carne (Ewe eje) - PressReader View abstract. Correspondence to Ethanol extracts of J. carnea leaf increased RBC, hemoglobin and platelet with significant increase (p<0.05) in groups that received higher dose (>500mg/kg b.w) of extract compared to the control. Antianaemic potentials of some plant extracts on phenyl hydrazineinduced anemia in rabbits. Justicia carnea [jus-TEE-see-ah, KAR-nee-uh] is popularly known as the Brazilian Plume Flower. Braz. The effects of ethanol extract of J. carnea leaf on total protein concentration and antioxidant system in liver and kidney of normal wistar rat is presented in Table 4. [4].Inflammationinjuries, in an attempt to heal is presented by five cardinal signs of heat (calor), redness (rubor), swelling (tumor), pain (dolor) and loss of function5.Studieshave demonstrated inflammation as being caused by The plant produces dark green leaves around 8 inches in length. The animals were randomly distributed into cages and allowed to acclimatize for 2 weeks in a well ventilated room under natural lighting condition. There is however little publications available on the pharmacological properties of the herbal plant. Meth Enzymol. Too much sun can scorch the leaves, and too little will result in fewer flowers. Medapa S, Singh GRJ, Ravikumar V. The phytochemical and antioxidant screening of Justicia wynaadensis. 16. The liver and kidney of rats administered with 500mg/kg JCEE and above demonstrated slight increase in MDA level with significant (P<0.05) increase only observed in the liver of rats that received 1200mg/kg of extract. The plant looks great along garden borders and near building foundations. J. Appl. 2003;84:99104. Higher doses (>500mg/kg) of extract significantly (p<0.05) increased RBC, hemoglobin and platelet compared to the control. The aim of this study is to evaluate the safety of ethanol extract of J. carnea leaf assessing the hematology indices, organ antioxidant system and histology in healthy male wistar rats. Blooming from early summer to fall, the flowers are attractive to hummingbirds and butterflies. Provided by the Springer Nature SharedIt content-sharing initiative. Hence, the use of Justicia carnea leaves may help reduce your risk of heart diseases, heart attack, stroke etc. Safety assessment of oral administration of ethanol extract of Justicia The in-vitro . In these groups, from mild to severe order; shows observable congested portal vein, the liver parenchyma showed area of harmorrhage, the morphology of the hepatocytes appear pyknotic, some show mild fat infiltration (red arrow) the sinusoids appear fibrotic with infiltration of inflammatory red cells (red arrow). The leaves are also rich source of vitamin A, vitamin C, and vitamin E. Another plant with this composition is pumpkin fruit. However, serious caution of the dose should be taken into consideration when extrapolating this result for human consumption. Section of livers and kidneys were excised and fixed in 10% formalin for histopathology examination. In sub-acute toxicity study, total of thirty (30) rats were randomized into six groups of five rats per group: Group 1 served as control and was administered with 1ml of distilled water (dH2O). Molecules (Basel, Switzerland), 19(12), 2144221461. SOD activity was determined by its ability to inhibit the auto-oxidation of epinephrine determined by the increase in absorbance at 480nm. Prepare the existing soil by breaking it up with a spade or hoe. When it comes to blood boosting and treatment of anemia, justicia carnea has proven beyond doubt to be an effective remedy. Biomed Res. Side effects of Ewe eje (Justicia carnea leaf Side Effects). This lends the plant some interesting names such as Blood of Jesus plant and Hospital too far. Exactly 1.0ml of tissues (liver and kidney) was deproteinised using 0.1ml of 10% TCA and centrifuged at 650g for 5min to obtain supernatant. View abstract. It is nicknamed the Blood leaf, Blood of Jesus, and Jehovah Witness leaf in Nigeria, and is a widely used leaf across states in Nigeria. Haematological and biochemical studies on Justicia carnea leave extract in phenylhydrazine induced-anemia in albino rats. 7 Potential Health Benefits Of Justicia Carnea (Ewe Eje) It is obvious that Justicia carnea has potential antianemic, antioxidant, antidiabetic, hepatoprotective, and immune-boosting properties. Ogwu obara can act as a blood tonic for women during menstruation. This claim have not been verified. 4. View abstract. The significant increase in MDA level at 1200mg/kg might be due to the presence of active secondary metabolites in the extracts that could have acted as prooxidant. Inter J Biochem Cell Bio. Buege JA, Aust SD. How Justicia Betonica is effective for various diseases is listed in repertory format. Google Scholar. A., Bezerra, G. A., Matos, F. J., and Viana, G. S. Antinociceptive, anti-inflammatory and bronchodilator activities of Brazilian medicinal plants containing coumarin: a comparative study. The species Justicia secunda Vahl belongs to the family - Acanthaceae - together with up to 600 other shrubs and herbs species. The major use of Justicia carnea leaves is to improve blood production. Hepatoprotective Effect of Methanol Extract of Justicia carnea Leaves While graded doses of J. carnea ethanol extract showed no significant difference in the liver and kidney GSH compared to the control, only rats that received 1200mg/kg body weight JCEE statistically decreased in the kidney. Research reports it isnt capable of causing kidney and liver damage either but dont eat it raw. Terms and Conditions, The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. There are several claims that justicia carnea can prevent epilepsy and convulsion among children. Eyong EU, Umoh IB, Ebong PE, Eteng MU, Antai AB, Akpa AO. The appropriate dose of Justicia pectoralis depends on several factors such as the user's age, health, and several other conditions. Methods. Elevated activity of catalase in liver and kidney across tested doses of J. carnea ethanol extract showed no significant effect compared to the control. Catalase activity (U/ml) was measured following the method of Sinha [17]. In various parts of Africa, several species of Justicia are used in traditional medicine for the treatment of anemia, inflammation, fever, diarrhea, liver diseases and arthritis respiratory and gastrointestinal disorder [8, 9]. One of the symptoms of diabetes is elevated blood glucose level. A multidisciplinary overview of intoxicating snuff rituals in the western hemisphere. Part of They should be watered regularly (once per week), but not overwatered. Acute and sub-acute toxicity studies of aqueous and methanol extracts of Nelsonia campestris in rats. The effect of the ethanol extract of Justicea carnea (JC) leaves in phenylhydrazine induced-anemia albino rats on haematological and lipid profile parameters was investigated. However, watch out for nematodes and spider mites. Occupational Health and Safety in the Care and Use of Research Animals. J Ethnopharmacol 1985;13(1):3-49. There should be further studies on the antidepressant activity of justicia carnea leaves. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Consequently, the effects of the extract on MDA level could indicate damage to cell membrane lipids of the hepatocyte which could result to increased generation of reactive oxygen species (ROS). 34-45. Paes-Leme AA, Motta ES, De Mattos JCP. 2007;112(1):13844. This requires more attention to properly document the various health benefits of justicia carnea. 1978;90:819. This is attributed to the anti-hyperlipidaemic properties of the plant. When you boil the plant, it turns the water red. Regular intake can reduce your risk of liver diseases like liver cirrhosis, hepatitis and liver inflammation. et al. Generally disease free. The concentration of reduced glutathione content of the tissues was estimated according to Sedlak and Lindsay [19] method. I do hope that after reading through this article, you would plan to start cultivating this amazing plant specie in your garden. Despite the therapeutic importance of medicinal plants, toxic substances have been shown to be present in large numbers of plants investigated [3]. Total protein concentration in tissue homogenates were determined using biuret method Tietz [16]. (2017). This also helps prevent self-seeding, which normally takes up a lot of the plants energy at the expense of flowering. PDF Effects of Ethanol Leaf Extract of Justicia Carnea on Biochemical Ewe eje can also be used to manage abnormalities associated with anaemia and for the treatment and management of diabetics. We use cookies on this website, you can read about them here. Decoction of ewe eje or its leaf extract can lower serum cholesterol and get rid of bad cholesterol (LDL). The research work was carried out in collaboration between all authors. Olaniyan JM, Hadiza LM, Hussaini AM, Musa BB, Abubakar SA. Kidney weight of rats treated with JCEE showed no significant difference with exception in 800mg/kg JCEE that demonstrated significant reduction. The cuttings are taken from the parent plant in the spring after the plant has bloomed. The non significant decrease observed in this study is in consonance with the work of Onyeabo et al., [9] who also reported no significant difference in the relative weights of liver and kidney. Briefly, 1.0ml of the sample was mixed with 2ml of TCA-TBA-HCl reagent (0.37% thiobarbituric acid, 15% trichloroacetic acid and 0.24N HCl in 1:1:1) and boiled at 100C in a water bath for 15min. 1. The resultant liquid after boiling is usually crimson red. In this study, the aqueous leaf extract of Justicia carnea was used. Justicia carnea has been used in traditional medicine to treat diabetes. Mean lethal dose of the extract was found to be above 5000mg/kg body weight (bw). Justicia carnea (Brazilian Plume) - Gardenia.net Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Akintimehin, E.S., Karigidi, K.O., Omogunwa, T.S. W Afr J Biol Sci. 2005 - 2023 WebMD LLC, an Internet Brands company. Justicia carnea does not cause miscarriage or congenital birth defects. The plant has various other common names including: Back in the day, the Justicia flower was boiled and used to solve anemia problems. The renal cortex showed normal glomeruli with mesangial cells and capsular spaces appeared normal (white arrow), the renal tubules appear normal (blue arrow) and interstitial spaces also observed normal (black arrow). PDF Biomedical Research 2019; 30 (4): 645-654 ISSN 0970-938X - Allied Academies 2008;79:3326 https://doi.org/10.1016/j.fitote.2008.02.005. The lush foliage and distinctive flowers make Brazilian Plume a natural for a tropical garden. The animals were initially examined for any signs of toxicity after 60min of administration and further observed for a period of 24h. The absence of rat mortality in phase I necessitated the conduct of the second phase. The flowers are slightly fragrant and mostly sterile. Some people would rather chew the leaves, while others add to meals or brew into a tea (in combination with other plants). Rats in the 3 different groups received 10, 100 and 1000mg/kg body weight of JCEE orally using oral gavage. This may be because of its hepatoprotective activity. Sample (or standard solution) (0.01ml) was mixed with diluted (1:4v/v distilled water) biuret reagent (100mM sodium hydroxide, 16mM sodium-potassium tartrate, 15mM potassium iodide and 6mM copper sulphate). Faiza R, Waqas KK, Adeel M, Muhammad G. Detection of bioactive fractions of Justicia adhatoda leaves. Afr J Tradit Complement Altern Med. It also grows in some Caribbean islands, including Trinidad and Tobago. This research focused on the safety and in vivo antioxidant status of healthy albino rats exposed to J. carnea leaf ethanol extract. Superoxide dismutase (SOD) activities were elevated across all doses in the liver with significant (p<0.05) difference only observed in the highest dose (1200mg/kg) while kidney showed no significant difference compared to the control. Philadelphia: WB. These compounds beyond boosting your blood concentration, thereby enhancing the transport of nutrients to various parts of the body, also boost your immune system against several infectious diseases. Rats were routinely observed for signs of toxicity. This encourages better flowering and bushier and denser new growth. They are also needed in strong bone formation, and in cellular and neuronal functions. For some, the boiling method is preferred while for others, soaking in hot water is more convenient. In a pot, pour in a cup of water and bring to a boil. They look terrific in properly shaded outside areas such as porches, patios, driveways, and entryways. As declared by all authors, no competing interests exist. Chemical constituents and biological activities of species of Justicia a review. 2012; 22(1):220238; https://doi.org/10.1590/S0102-695X2011005000196. International Journal of Biochemistry Research & Review. 2012;9(1):817 https://doi.org/10.4314/ajtcam.v9i1.12. Effect of the ethanol extract of Justicia carnea leaves on the red volume7, Articlenumber:2 (2021) Effect of methanol leaf extract of Justicia carnea on serum albumin (ALB) and total protein (TP) concentration CCl 4 intoxicated rats. Two of the most important soil considerations include fertility and drainage. Keep an eye out for glasshouse red spider mite and glasshouse whitefly. https://doi.org/10.1016/j.biocel.2006.07.001. Phytother Res 2011;25(3):444-450. statement and Summer temperatures above 77 degrees Fahrenheit (25 C) are perfect. Oyenihi OR, Brooks NL, Oguntibeju OO. It may be, judging from the antidepressant activity of other plant of justicia species whose activity have been studied, proper to state that justicia carnea may possess antidepressant properties.